New research indicates that patients who discontinue popular weight-loss injections like Wegovy and Mounjaro may regain shed pounds far faster than those who halt conventional diet and exercise regimens.
Research printed in a leading health publication points out that while obese people often shed a large proportion of their body weight while on the medication, the mass comes back at an average rate of 0.8 kg per month once they quit.
"People buying these drugs need to be informed of the potential of rapid rebound weight gain when the medication is stopped," cautioned expert Dr. Susan Jebb.
This pace of recovery means a return to starting weight in about a year and a half.
Analyzing Treatments
The research, which reviewed 37 of studies involving thousands of participants, compared the effects of the injectable medications with other pills.
Scientists point out that individuals who lose weight through lifestyle changes alone usually see a slower weight regain—around 100 grams monthly—after stopping.
Understanding the Fast Regain
Doctors believe the mode of action of the drugs accounts for the amplified weight return.
These medications copy a body's own chemical called GLP-1, which helps regulate hunger.
"Sustained high doses of GLP-1 concentrations far above than normal could lead to the body to generate a reduced amount of its own natural hormone, and could lessen sensitivity to its actions," noted Dr. Adam Collins, a nutrition expert.
"Discontinuation of this GLP-1 'fix' results in appetite is unsuppressed, making excessive eating far more likely."
An Ongoing Condition?
The NHS recommend the injections for individuals with obesity-related medical conditions, accompanied by recommended diet and exercise modifications.
Professionals say that, given the likelihood of relapse, the treatment might need to be life-long.
This opinion is supported by drug manufacturers, who note that the findings "underscore the persistent character of excess weight," similar to managing diseases like hypertension.
User Experiences
Users who have come off the jabs explain a sudden resurgence of cravings.
"It was like a trigger flipping and you become ravenous," described a patient.
The struggle is exacerbated if users have not developed sustainable dietary or behavioural changes during treatment.
Widespread Adoption
Survey data suggest that millions of people in the UK have used these injections in the past year, with demand remaining high.
- Use is higher among women than males.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion obtain the medications through private prescriptions rather than public health services.
In conclusion, experts stress that while the jabs are effective agents for shedding pounds, they are not a permanent cure and lasting health benefits likely depends on ongoing behavioural management.
